學歷
-
中國醫藥大學牙醫學士，民國八十五年
-
國立臺灣大學牙醫碩士，民國八十八年
-
國立臺灣大學牙醫博士，民國九十六年
經歷
- Visiting scholar, School of Dentistry, Medical College of Georgia, 2003-2004
- 國立臺灣大學牙醫系講師，民國九十七年-一零二年
- 國立臺灣大學牙醫系助理教授，民國一零二年-一一二年
- 臺灣大學醫學院附設醫院牙科部主治醫師，民國九十七年-迄今
- 牙科材料學、材料細胞毒性、美容牙科、牙體復形科
材料學、細胞毒性學
Biological effects of dental resin monomers
The dental resin composite is widely used in modern dentistry. The cytotoxic effect of dental resin composite on cells is also more and more important. The previous researches showed that the high concentration of dental composite monomer presented the high toxicity; however, the extra-low concentration of dental resin composite monomer showed the tendency to increase the growth of cells. The pathway of the effects of high and extra-low concentration of resin monomer is still needed to be investigated.
Dental resin composites and dental bonding systems are extensively utilized in modern dentistry due to their aesthetic appeal and versatility. The biological effects of these materials on cells have become increasingly significant. Previous studies have demonstrated that high concentrations of dental resin monomers exhibit substantial toxicity, whereas extremely low concentrations tend to promote cell growth. Understanding the pathways through which high and low concentrations of resin monomers exert their effects remains a crucial area for further investigation.
The advent of Next Generation Sequencing (NGS) has revolutionized the dental field This technology can potentially uncover novel insights into how dental resin composites interact with human cells, thereby influencing their biocompatibility and long-term efficacy. Therefore, integrating NGS into research on dental resin composites is essential for advancing our understanding of their biological impacts and optimizing their development for safer and more effective dental restorations.
The polymerization and shrinkage of dental resin composite
The degree of polymerization of dental resin composites significantly influences both the mechanical properties and the outcome of dental treatment. Inadequate polymerization can lead to reduced mechanical strength and increased cytotoxicity.
Additionally, polymerization shrinkage is a critical factor affecting the longevity of resin restorations. This shrinkage can create microgaps and induce Stress: Causing postoperative sensitivity and potential debonding of the restorations. Therefore, understanding how different curing modes and light sources affect the properties of resin composites is of paramount importance in clinical restorative dentistry. This knowledge could help to guides material selection, optimizes curing techniques, and enhances patient outcomes. By investigating these factors, dental professionals can improve the quality and longevity of dental restorations, ultimately enhancing patient care and satisfaction.
The surface modification of dental implants
Dental implants represent one of the most rapidly advancing treatments in recent decades. Surface treatment of implants involves processing the artificial root to impart specific biological functionalities, creating an environment conducive to bone cell attachment and growth. This accelerates bone cell differentiation and mineralization, facilitating bone healing in the shortest possible time. Our research employs Atomic Layer Deposition Technique (ALD) and Micro-Arc Oxidation (MAO) combined with Hydrothermal Techniques to modify the surface of dental implant materials at both micro- and nano- scales. We assess the impact of these modifications on cell functional differentiation and use Next Generation Sequencing (NGS) technology to identify key factors that accelerate cell mineralization, thereby reducing clinical waiting times for patients.
