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網站導覽 台大醫學院 台大醫院 台灣大學
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陳信銘
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陳信銘

陳信銘 副教授

牙醫學系

口腔顎面外科學

光動力治療、口腔癌、口腔植體學、身心障礙者牙科醫療研究

23123456 ext 267405

hmcnew2023@gmail.com

  • 中山醫學院牙醫學士，民國七十六年 

  • 國立台灣大學牙醫學碩士，民國八十一年 

  • 國立台灣大學臨床牙醫學博士，民國九十二年

02 學術著作

  1. 口腔黏膜下纖維化症致病機轉與治療之研究
  2. 運用自體螢光診斷口腔癌及口腔癌前病變之研究
  3. 運用光動力治療方法治療口腔癌及口腔癌前病變之研究
  4. 口腔癌及口腔癌前病變預防牙醫學之研究
    (1) 口腔癌及口腔癌前病變篩檢輔助工具效度之研究
    (2) 治療口腔癌及口腔癌前病變經濟耗損之研究
    (3) 口腔癌及口腔癌前病變化學預防藥物與機轉之研究
  5. 牙科專科醫師人力供需之研究

  1. Chang CH, Wu YC, Wu YH, Sun A, Cheng SJ and Chen HM (2017). Significant association of high-grade inflammation and thick lining epithelium with the increased number of Langerhans cells in dentigerous cysts. Journal of the Formosan Medical Association 116(11): 837-843. (SCI)
  2. Chang CH, Wu YC, Wu YH, Sun A, Cheng SJ and Chen HM (2017). Significant association of inflammation grade with the number of Langerhans cells in odontogenic keratocysts. Journal of the Formosan Medical Association 116(10): 798-805. (SCI)
  3. Wu YH, Wang YP, Chang JYF, Wu YC, Chen HM and Sun A (2017). Anemia and hematinic deficiencies in oral mucosal disease patients with microcytosis. Journal of the Formosan Medical Association 116(7): 505-511. (SCI)
  4. Wu YH, Chang JYF, Wang YP, Wu YC, Chen HM and Sun A (2017). Anemia and hematinic deficiencies in anti-gastric parietal cell antibody- positive and-negative recurrent aphthous stomatitis patients with anti-thyroid antibody positivity. Journal of the Formosan Medical Association 116(3): 145-152. (SCI)
  5. Wu YC, Wu YH, Wang YP, Chang JYF, Chen HM and Sun AD (2017). Antigastric parietal cell and antithyroid autoantibodies in patients with recurrent aphthous stomatitis. Journal of the Formosan Medical Association 116(1): 4-9. (SCI)
  6. Wang YP, Chen IC, Wu YH, Wu YC, Chen HM and Chang JYF (2017). Langerhans cell counts in oral epithelial dysplasia and their correlation to clinicopathological parameters. Journal of the Formosan Medical Association 116(6): 457-463. (SCI)
  7. Ko HH, Cheng SL, Lee JJ, Chen HM, Kuo MYP and Cheng SJ (2017). Expression of AKR1B10 as an independent marker for poor prognosis in human oral squamous cell carcinoma. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 39(7): 1327-1332. (SCI)
  8. Hsieh YP, Chen HM, Lin HY, Yang H and Chang JZC (2017). Epigallocatechin-3-gallate inhibits transforming-growth-factor-beta 1-induced collagen synthesis by suppressing early growth response-1 in human buccal mucosal fibroblasts. Journal of the Formosan Medical Association 116(2): 107-113. (SCI)
  9. Chang JZC, Hsieh YP, Lin WH, Chen HM and Kuo MYP (2017). Activation of transforming growth factor-1 by thrombin via integrins v1, v3, and v5 in buccal fibroblasts: Suppression by epigallocatechin-3-gallate. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 39(7): 1436-1445. (SCI)
  10. Chang JYF, Chiang CP, Wang YP, Wu YC, Chen HM and Sun A (2017). Antigastric parietal cell and antithyroid autoantibodies in patients with desquamative gingivitis. Journal of Oral Pathology & Medicine 46(4): 307-312. (SCI)
  11. Yeh CY, Lin CL, Chang MC, Chen HM, Kok SH, Chang SH, Kuo YS, Hahn LJ, Chan CP, Lee JJ and Jeng JH (2016). Differences in oral habit and lymphocyte subpopulation affect malignant transformation of patients with oral precancer. Journal of the Formosan Medical Association 115(4): 263-268. (SCI)
  12. Yeh CY, Chen HM, Chang MC, Kok SH, Lee JJ, Chang BE, Jeng PY, Chan CP and Jeng JH (2016). Cytotoxicity and transformation of C3H10T1/2 cells induced by areca nut components. Journal of the Formosan Medical Association 115(2): 108-112. (SCI)
  13. Wu YH, Yang H, Sun A and Chen HM (2016). Kaposi's sarcoma of the hard palate. Journal of the Formosan Medical Association 115(10): 883-884. (SCI)
  14. Wu YC, Wu YH, Wang YP, Chang JYF, Chen HM and Sun A (2016). Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis. Journal of the Formosan Medical Association 115(12): 1061-1068. (SCI)
  15. Wu YC, Wang YP, Cheng SJ, Chen HM, Sun AD and Chang JYF (2016). Clinicopathological study of 74 palatal pleomorphic adenomas. Journal of the Formosan Medical Association 115(1): 25-30. (SCI)
  16. Sun A, Chang JYF, Wang YP, Cheng SJ, Chen HM and Chiang CP (2016). Effective vitamin B12 treatment can reduce serum antigastric parietal cell antibody titer in patients with oral mucosal disease. Journal of the Formosan Medical Association 115(10): 837-844. (SCI)
  17. Sun A, Chang JYF, Wang YP, Cheng SJ, Chen HM and Chiang CP (2016). Do all the patients with vitamin B12 deficiency have pernicious anemia? Journal of Oral Pathology & Medicine 45(1): 23-27. (SCI)
  18. Lin PY, Wang KW, Tu YK, Chen HM, Chi LY and Lin CP (2016). Dental service use among patients with specific disabilities: A nationwide population-based study. Journal of the Formosan Medical Association 115(10): 867-875. (SCI)
  19. Ko HH, Cheng SL, Lee JJ, Chen HM, Wang CW, Cheng SJ and Kok SH (2016). Factors influencing the incidence and prognosis of second primary tumors in patients with oral squamous cell carcinoma. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 38(10): 1459-1466. (SCI)
  20. Cheng SJ, Chang CF, Lee JJ, Chen HM, Wang HJ, Liou YL, Yen C and Chiang CP (2016). Hypermethylated ZNF582 and PAX1 are effective biomarkers for detection of oral dysplasia and oral cancer. Oral Oncology 62: 34-43. (SCI)
  21. Chen HY, Yang H, Meng LF, Chan PYS, Yang CY and Chen HM (2016). Effect of deep pressure input on parasympathetic system in patients with wisdom tooth surgery. Journal of the Formosan Medical Association 115(10): 853-859. (SCI)
  22. Chang JYF, Chen IC, Wang YP, Wu YH, Chen HM and Sun A (2016). Anemia and hematinic deficiencies in gastric parietal cell antibody-positive and antibody-negative erosive oral lichen planus patients with thyroid antibody positivity. Journal of the Formosan Medical Association 115(11): 1004-1011. (SCI)
  23. Wu YH, Chang JYF, Chen HM and Wang YP (2015). Pyostomatitis vegetans: An oral manifestation of inflammatory bowel disease. Journal of the Formosan Medical Association 114(7): 672-673. (SCI)
  24. Wu YC, Wang YP, Liu YC and Chen HM (2015). Langerhans cells in the lining epithelium of unicystic ameloblastoma. Journal of Dental Sciences 10(4): 464-466. (SCI)
  25. Wang YP, Wu YC, Cheng SJ, Chen HM, Sun A and Chang JYF (2015). High frequencies of vitamin B-12 and folic acid deficiencies and gastric parietal cell antibody positivity in oral submucous fibrosis patients. Journal of the Formosan Medical Association 114(9): 813-819. (SCI)
  26. Wang YC, Huang GF, Cheng YJ, Chen HM, Yang H, Lin CP, Huang HH and Huang CH (2015). Analysis of clinical characteristics, dental treatment performed, and postoperative complications of 200 patients treated under general anesthesia in a special needs dental clinic in northern Taiwan. Journal of Dental Sciences 10(2): 172-175. (SCI)
  27. Tseng CH, Wang YP, Chen HM and Chang JYF (2015). Hyaluronic acid injection-induced delayed-onset foreign body granuloma. Journal of Dental Sciences 10(3): 341-343. (SCI)
  28. Sun A, Chen HM, Cheng SJ, Wang YP, Chang JYF, Wu YC and Chiang CP (2015). Significant association of deficiencies of hemoglobin, iron, vitamin B12, and folic acid and high homocysteine level with recurrent aphthous stomatitis. Journal of Oral Pathology & Medicine 44(4): 300-305. (SCI)
  29. Shen WR, Chang JYF, Wu YC, Cheng SJ, Chen HM and Wang YP (2015). Oral traumatic ulcerative granuloma with stromal eosinophilia: A clinicopathological study of 34 cases. Journal of the Formosan Medical Association 114(9): 881-885. (SCI)
  30. Sar JIC, Yang CJ, Tsai YS, Deng YT, Chen HM, Chang HH and Liu CM (2015). Sphingosine-1-phosphate stimulated connective tissue growth factor expression in human buccal fibroblasts: Inhibition by epigallocatechin-3-gallate. Journal of the Formosan Medical Association 114(9): 860-864. (SCI)
  31. Lang MJ, Wang YP, Lin HP, Chen HM and Kuo YS (2015). Adenomatoid odontogenic tumor-Report of a posterior mandibular case with the presence of ghost cells. Journal of Dental Sciences 10(2): 216-222. (SCI)
  32. Ko HH, Lee JJ, Chen HM, Kok SH, Kuo MYP, Cheng SJ and Chiang CP (2015). Upregulation of vascular endothelial growth factor mRNA level is significantly related to progression and prognosis of oral squamous cell carcinomas. Journal of the Formosan Medical Association 114(7): 605-611. (SCI)
  33. Hsieh YP, Chen HM, Chang JZC, Chiang CP, Deng YT and Kuo MYP (2015). Arecoline stimulated early growth response-1 production in human buccal fibroblasts: Suppression by epigallocatechin-3-gallate. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 37(4): 493-497. (SCI)
  34. Chiang CP, Yang H and Chen HM (2015). Focal osteoporotic marrow defect of the maxilla. Journal of the Formosan Medical Association 114(2): 192-194. (SCI)
  35. Cheng SJ, Chen HM and Chiang CP (2015). Cryogun cryotherapy is the first-line treatment of choice for oral leukoplakia. Journal of Dental Sciences 10(2): 223-224. (SCI)
  36. Chen HM, Wang YP, Chang JYF, Wu YC, Cheng SJ and Sun A (2015). Significant association of deficiencies of hemoglobin, iron, folic acid, and vitamin B-12 and high homocysteine level with oral lichen planus. Journal of the Formosan Medical Association 114(2): 124-129. (SCI)
  37. Chen HM, Cheng SJ, Lin HP, Yu CH, Wu YC and Chiang CP (2015). Cryogun cryotherapy for oral leukoplakia and adjacent melanosis lesions. Journal of Oral Pathology & Medicine 44(8): 607-613. (SCI)
  38. Chen HM, Cheng SJ and Chiang CP (2015). Topical photodynamic therapy is the first-line treatment of choice for oral erythroleukoplakia and oral verrucous hyperplasia. Journal of the Formosan Medical Association 114(7): 567-568. (SCI)
  39. Chang JYF, Wang YP, Wu YC, Cheng SJ, Chen HM and Sun A (2015). Hematinic deficiencies and pernicious anemia in oral mucosal disease patients with macrocytosis. Journal of the Formosan Medical Association 114(8): 736-741. (SCI)
  40. Chang JYF, Wang YP, Wu YC, Cheng SJ, Chen HM and Sun A (2015). Hematinic deficiencies and anemia statuses in oral mucosal disease patients with folic acid deficiency. Journal of the Formosan Medical Association 114(9): 806-812. (SCI)
  41. Chang JYF, Wang YP, Wu YC, Cheng SJ, Chen HM and Sun A (2015). Blood profile of oral mucosal disease patients with both vitamin B-12 and iron deficiencies. Journal of the Formosan Medical Association 114(6): 532-538. (SCI)
  42. 洪孟豪, 郭生興, 李正喆, 陳信銘, 章浩宏 and 鄭世榮 (2014). 妊娠期孕婦因齒源性感染引發嚴重深頸感染之處置－病例報告. 臺灣口腔顎面外科學會雜誌 25: 50-58.
  43. 柳依青, 郭生興, 李正喆, 陳信銘, 章浩宏 and 鄭世榮 (2014). 上顎前牙造釉細胞瘤之手術處理及重建－病例報告. 臺灣口腔顎面外科學會雜誌 25: 186-194.
  44. Yu SY, Wang YP, Chang JYF, Shen WR, Chen HM and Chiang CP (2014). Increased expression of MCM5 is significantly associated with aggressive progression and poor prognosis of oral squamous cell carcinoma. Journal of Oral Pathology & Medicine 43(5): 344-349. (SCI)
  45. Yu CH, Lin HP, Cheng SJ, Sun A, Chen HM (2014). Cryotherapy for oral precancers and cancers. Journal of the Formosan Medical Association 113 (5): 272-7. (SCI)
  46. Yang DF, Lee JW, Chen HM, Huang Z and Hsu YC (2014). Methotrexate enhances 5-aminolevulinic acid-mediated photodynamic therapy-induced killing of human SCC4 cells by upregulation of coproporphyrinogen oxidase. Journal of the Formosan Medical Association 113(2): 88-93. (SCI)
  47. Yang DF, Lee JW, Chen HM and Hsu YC (2014). Topical methotrexate pretreatment enhances the therapeutic effect of topical 5-aminolevulinic acid-mediated photodynamic therapy on hamster buccal pouch precancers. Journal of the Formosan Medical Association 113(9): 591-599. (SCI)
  48. Wu YC, Wang YP, Chang JYF, Cheng SJ, Chen HM and Sun A (2014). Oral manifestations and blood profile in patients with iron deficiency anemia. Journal of the Formosan Medical Association 113(2): 83-87. (SCI)
  49. Wang YP, Lin HP, Chen HM, Kuo YS, Lang MJ and Sun A (2014). Hemoglobin, iron, and vitamin B12 deficiencies and high blood homocysteine levels in patients with anti-thyroid autoantibodies. Journal of the Formosan Medical Association 113(3): 155-160. (SCI)
  50. Lee JJ, Yang FY, Wu YC, Chen HM (2014). Metastatic lung carcinoma to the lower anterior gingiva. Journal of the Formosan Medical Association 113(12):978-80. (SCI)
  51. Shen WR, Wang YP, Chang JYF, Yu SY, Chen HM and Chiang CP (2014). Perineural invasion and expression of nerve growth factor can predict the progression and prognosis of oral tongue squamous cell carcinoma. Journal of Oral Pathology & Medicine 43(4): 258-264. (SCI)
  52. Chen HY, Yang H, Chi HJ and Chen HM (2014). Physiologic and behavioral effects of papoose board on anxiety in dental patients with special needs. Journal of the Formosan Medical Association 113(2): 94-101. (SCI)
  53. Chen HM, Wu YC, Wei LY and Chiang CP (2014). Metastatic hepatocellular carcinoma of the anterior palatal gingiva. Journal of Dental Sciences 9(2): 202-204. (SCI)
  54. Yu CH, Chen HM, Lin HP and Chiang CP (2013). Expression of Bak and Bak/Mcl-1 ratio can predict photodynamic therapy outcome for oral verrucous hyperplasia and leukoplakia. Journal of Oral Pathology & Medicine 42(3): 257-262. (SCI)
  55. Wu YC, Wang YP, Chang JYF, Chen HM, Sun A and Chiang CP (2013). Langerhans cells in odontogenic epithelia of odontogenic fibromas. Journal of the Formosan Medical Association 112(12): 756-760. (SCI)
  56. Wu KM, Wang YP, Lin HP, Chen HM, Chia JS and Sun AD (2013). Modulation of serum smooth muscle antibody levels by levamisole treatment in patients with oral lichen planus. Journal of the Formosan Medical Association 112(6): 352-357. (SCI)
  57. Wang YP, Chang JYF, Wu YC, Cheng SJ, Chen HM and Sun A (2013). Oral manifestations and blood profile in patients with thalassemia trait. Journal of the Formosan Medical Association 112(12): 761-765. (SCI)
  58. Sun A, Wu KM, Wang YP, Lin HP, Chen HM and Chiang CP (2013). Burning mouth syndrome: a review and update. Journal of Oral Pathology & Medicine 42(9): 649-655. (SCI)
  59. Sun A, Lin HP, Wang YP, Chen HM, Cheng SJ and Chiang CP (2013). Significant reduction of serum homocysteine level and oral symptoms after different vitamin-supplement treatments in patients with burning mouth syndrome. Journal of Oral Pathology & Medicine 42(6): 474-479. (SCI)
  60. Lin HP, Wang YP, Chen HM, Kuo YS, Lang MJ and Sun A (2013). Significant association of hematinic deficiencies and high blood homocysteine levels with burning mouth syndrome. Journal of the Formosan Medical Association 112(6): 319-325. (SCI)
  61. Lin HP, Wang YP, Chen HM, Cheng SJ, Sun A and Chiang CP (2013). A clinicopathological study of 338 dentigerous cysts. Journal of Oral Pathology & Medicine 42(6): 462-467. (SCI)
  62. Lee JJ, Cheng SJ, Wang JJ, Chiang CP, Chang HH, Chen HM and Kok SH (2013). Factors predicting the prognosis of oral alendronate-related osteonecrosis of the jaws: A 4-year cohort study. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 35(12): 1787-1795. (SCI)
  63. Cheng SJ, Liu YC, Cheng SL, Lee JJ, Chen HM, Chang HH, Kok SH, Kuo MYP and Chiang CP (2013). Expression of G alpha 12 predicts progression and prognosis of oral squamous cell carcinomas in Taiwan. Journal of Oral Pathology & Medicine 42(7): 565-569. (SCI)
  64. Cheng SJ, Wang YP, Chen HM and Chiang CP (2013). Central granular cell odontogenic tumor of the mandible. Journal of the Formosan Medical Association 112(9): 583-585. (SCI)
  65. Chen HY, Yang H, Chi HJ and Chen HM (2013). Physiological Effects of Deep Touch Pressure on Anxiety Alleviation: The Weighted Blanket Approach. Journal of Medical and Biological Engineering 33(5): 463-470. (SCI)
  66. Chen HM (2013). Langerhans cells in odontogenic epithelium. Journal of the Formosan Medical Association 112(9): 586-586. (SCI)
  67. Chang JZC, Yang WH, Deng YT, Chen HM and Kuo MYP (2013). EGCG blocks TGF beta 1-induced CCN2 by suppressing JNK and p38 in buccal fibroblasts. Clinical Oral Investigations 17(2): 455-461. (SCI)
  68. Lin IH, Fan SZ, Chen HM, Lee JJ, Cheng SJ, Chang HH, Chan WH (2013). Changes in biomarkers of hepatic and renal function after prolonged general anesthesia for oral cancer surgery: A cohort comparison between desflurane and sevoflurane. Journal of Dental Sciences 8(4):385-91. (SCI)
  69. Sun A, Wang YP, Lin HP, Chen HM, Cheng SJ, Chiang CP (2013). Significant reduction of homocysteine level with multiple B vitamins in atrophic glossitis patients. Oral Diseases 19(5):519-24. (SCI)
  70. Cheng SJ, Ko HH, Cheng SL, Lee JJ, Chen HM, Chang HH, Kok SH, Kuo MY, Chiang CP (2013). Arecoline-stimulated placenta growth factor production in gingival epithelial cells: modulation by curcumin. Oral Diseases 19(5): 513-8. (SCI)
  71. Cheng SJ, Cheng SL, Lee JJ, Chen HM, Chang HH, Kok SH, Chiang ML, Kuo MY (2013). Increased placenta growth factor mRNA level is significantly associated with progression, recurrence and poor prognosis of oral squamous cell carcinoma. Journal of the Formosan Medical Association 112(5):253-8. (SCI)
  72. Wu PH, Lin SK, Lee BS, Kok SH, Wang JH, Hou KL, Yang H, Lai EHH, Wang JS, Hong CY (2012). Epigallocatechin-3-gallate diminishes cytokine-stimulated Cyr61 expression in human osteoblastic cells: a therapeutic potential for arthritis. Rheumatology 51(11):1953-65. (SCI)
  73. Ho MH, Chiang CP, Liu YF, Kuo MYP, Lin SK, Lai JY, Lee BS (2011). Highly Efficient Release of Lovastatin from Poly(Lactic-co-Glycolic Acid) Nanoparticles Enhances Bone Repair in Rats. Journal of Orthopaedic Research 29(10):1504-10. (SCI)
  74. Lee BS, Huang LC, Hong CY, Wang SG, Hsu WH, Yamauchi Y, Hsieh CJ, Lai JY, Wu KCW (2011). Synthesis of metal ion-histidine complex functionalized mesoporous silica nanocatalysts for enhanced light-free tooth bleaching. Acta Biomaterialia 7(5):2276-84. (SCI)
  75. Lee BS, Wang CY, Fang YY, Hsieh KH, Lin CP (2011). A Novel Urethane Acrylate-based Root Canal Sealer with Improved Degree of Conversion, Cytotoxicity, Bond Strengths, Solubility, and Dimensional Stability. Journal of Endodontics 37(2):246-49. (SCI)
  76. Yeh ST, Wang HT, Liao HY, Su SL, Chang CC, Kao HC, Lee BS (2011). The roughness, microhardness, and surface analysis of nanocomposites after application of topical fluoride gels. Dental Materials 27(2):187-96. (SCI)
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