Prof. Sang-Heng Kok

Education

• DDS, National Taiwan University, 1983

• PhD, National Taiwan University, 2003

Experience

• Diploma of Oral and Maxillofacial Surgery  National Taiwan University, 1989

• Associate Professor   National Taiwan University, 2003

• Division Head of Oral and Maxillofacial Surgery  National Taiwan University Hospital, 2007

Pathogenesis and Treatment of Oral Cancers

Using techniques in molecular biology to study the changes of oncogenes, tumor suppressor genes and other genetic markers in oral cancers. Correlating the clinical parameters with the genetic changes to found a database of molecular epidemiology for oral cancers in Taiwan. According to the above information to establish rational protocols for prevention and treatment of oral cancers.

Oral Implantology

Biological responses and clinical applications of various forms of dental implants. The efficacy of various bone graft procedures in conjunction with implant surgery.

Orthognathic Surgery:

Clinical efficacy of various orthognathic procedures, especially focused on surgery for jaw asymmetry.

Osteoimmunology:

Cellular and molecular mechanisms underlying bone destruction in various dental diseases.

1. Chen YJ, Tsai CY, Chang ZC, Yao CC, Kok SH (2024, Dec). Differential outcomes of jaw bone position after surgical-orthodontic treatment in three types of skeletal Class III asymmetry patients. JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 123(12):1294-1302.
2. Tseng CF, Lee IT, Wu SH, Chen HM, Mine Y, Peng TY, Kok SH (2024, Oct). Effects of handheld nonthermal plasma on the biological responses, mineralization, and inflammatory reactions of polyaryletherketone implant materials. JOURNAL OF DENTAL SCIENCES, 19(4):2018-2026.
3. Tseng CF, Chen HM, Liao TL, Hsu FT, Yeh CJ, Chen WT, Kok SH (2024, Sep). Magnolol's therapeutic efficacy and immunomodulatory effects in oral squamous cell carcinoma. IN VIVO, 38(5):2152-2164.
4. Lin SK, Wang HW, Shun CT, Yang CN, Hong CY, Lai EH, Cheng SJ, Chen MH, Yang H, Lin HY, Wu FY, Kok SH (2023, Nov). Sirtuin 6 ameliorates arthritis through modulating cyclic AMP-responsive element binding protein/CCN1/cyclooxygenase 2 pathway in osteoblasts. JOURNAL OF BONE AND MINERAL METABOLISM, 41(6):772-784.
5. Hong CY, Lin SK, Wang HW, Shun CT, Yang CN, Lai EH, Cheng SJ, Chen MH, Yang H, Lin HY, Wu FY, Kok SH (2023, Sep). Metformin reduces bone resorption in apical periodontitis through regulation of osteoblast and osteoclast differentiation. JOURNAL OF ENDODONTICS, 49(9):1129-1137.
6. Chen YJ, Yao CC, Chang ZC, Lai HH, Hsu LF, Hsu TH, Kok SH (2023, Apr). Occlusal function and electromyographic activity of masticatory muscles in skeletal Class III patients with different patterns of mandibular asymmetry. JOURNAL OF ORAL REHABILITATION, 50(4):276-285.
7. Wang HW, Lai EH, Yang CN, Lin SK, Hong CY, Yang H, Chang JZ, Kok SH (2020, Jan). Intracanal metformin promotes healing of apical periodontitis via suppressing inducible nitric oxide synthase expression and monocyte recruitment. JOURNAL OF ENDODONTICS, 46(1):65-73. (Honarable Mention 2021)