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Mark Yen-Ping Kuo
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Mark Yen-Ping Kuo

Prof. Mark Yen-Ping Kuo

Dentistry Dept.

Periodontics, Oral Molecular Biology

Periodontics、Oral Molecular Biology

23123456 ext 267412

oddie@ntu.edu.tw

  • D.D.S., Dentistry, National Taiwan University, 1982 

  • Ph. D., Molecular Biology, University of Pennsylvania, USA, 1989

02 Publications

  1. Molecular pathogenesis of areca-quid chewing related oral diseases: oral cancer, oral submucous fibrosis
  2. Development of novel strategies for the treatment of oral cancer and oral oral submucous fibrosis, including target therapy, gene therapy and new chemotherapeutic agents
  3. Roles of periodontal pathogens in the development of atherosclerosis
  4. Cancer and periodontal stem cells

  1. Chen YF, Yuan A, Cho KH, Lu YC, Kuo MYP, Chen JH and Chang YC (2017). Functional evaluation of therapeutic response of HCC827 lung cancer to bevacizumab and erlotinib targeted therapy using dynamic contrast-enhanced and diffusion-weighted MRI. Plos One 12(11). (SCI)
  2. Yan JJ, Kuo MYP and Chiang CP (2017). Free palatal mucosal graft for treatment of erosive oral lichen planus. Journal of the Formosan Medical Association 116(7): 560-562. (SCI)
  3. Wu TS, Tan CT, Chang CC, Lin BR, Lai WT, Chen ST, Kuo MYP, Rau CL, Jaw FS and Chang HH (2017). B-cell lymphoma/leukemia 10 promotes oral cancer progression through STAT1/ATF4/S100P signaling pathway (vol 34, pg 1207, 2015). Oncogene 36(38): 5440-5440. (SCI)
  4. Li YJ, Lai WT, Chang CC, Kuo MYP, Deng YT, Yang CN, Cheng SJ, Wu TS, Chen ST and Lin BR (2017). Ataxia-telangiectasia mutated interactor regulates head and neck cancer metastasis via KRas expression. Oral Oncology 66: 100-107. (SCI)
  5. Ko HH, Cheng SL, Lee JJ, Chen HM, Kuo MYP and Cheng SJ (2017). Expression of AKR1B10 as an independent marker for poor prognosis in human oral squamous cell carcinoma. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 39(7): 1327-1332. (SCI)
  6. Chang JZC, Hsieh YP, Lin WH, Chen HM and Kuo MYP (2017). Activation of transforming growth factor-1 by thrombin via integrins v1, v3, and v5 in buccal fibroblasts: Suppression by epigallocatechin-3-gallate. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 39(7): 1436-1445. (SCI)
  7. Chang CC, Yang YJ, Li YJ, Chen ST, Lin BR, Wu TS, Lin SK, Kuo MYP and Tan CT (2017). MicroRNA-17/20a functions to inhibit cell migration and can be used a prognostic marker in oral squamous cell carcinoma (vol 49, pg 923, 2013). Oral Oncology 72: 202-203. (SCI)
  8. Yeh CC, Ko HH, Hsieh YP, Wu KJ, Kuo MYP and Deng YT (2016). Phenethyl isothiocyanate enhances TRAIL-induced apoptosis in oral cancer cells and xenografts. Clinical Oral Investigations 20(9): 2343-2352. (SCI)
  9. Yang WH, Deng YT, Hsieh YP, Wu KJ and Kuo MYP (2016). Thrombin Activates Latent TGF beta 1 via Integrin alpha v beta 1 in Gingival Fibroblasts. Journal of Dental Research 95(8): 939-945. (SCI)
  10. Wu PH, Chung HY, Wang JH, Shih JC, Kuo MYP, Chang PC, Huang YD, Wang PC and Chang CC (2016). Amniotic membrane and adipose-derived stem cell co-culture system enhances bone regeneration in a rat periodontal defect model. Journal of the Formosan Medical Association 115(3): 186-194. (SCI)
  11. Liu YP, Lee JJ, Lai TC, Lee CH, Hsiao YW, Chen PS, Liu WT, Hong CY, Lin SK, Kuo MYP, Lu PJ and Hsiao M (2016). Suppressive function of low-dose deguelin on the invasion of oral cancer cells by downregulating tumor necrosis factor alpha-induced nuclear factor-kappa B signaling. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 38: E524-E534. (SCI)
  12. Li YJ, Huang TH, Hsiao M, Lin BR, Cheng SJ, Yang CN, Lai WT, Wu TS, Fan JR, Kuo MYP and Chang CC (2016). Suppression of fructose-bisphosphate aldolase C expression as a predictor of advanced oral squamous cell carcinoma. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 38: E1075-E1085. (SCI)
  13. Yeh CC, Chang JZC, Yang WH, Chang HH, Lai EHH and Kuo MYP (2015). NADPH oxidase 4 is involved in the triethylene glycol dimethacrylate-induced reactive oxygen species and apoptosis in human embryonic palatal mesenchymal and dental pulp cells. Clinical Oral Investigations 19(6): 1463-1471. (SCI)
  14. Yang WH, Deng YT, Hsieh YP, Wu KJ and Kuo MYP (2015). NADPH Oxidase 4 Mediates TGF beta 1-induced CCN2 in Gingival Fibroblasts. Journal of Dental Research 94(7): 976-982. (SCI)
  15. Yang CN, Deng YT, Tang JY, Cheng SJ, Chen ST, Li YJ, Wu TS, Yang MH, Lin BR, Kuo MYP, Ko JY and Chang CC (2015). MicroRNA-29b regulates migration in oral squamous cell carcinoma and its clinical significance. Oral Oncology 51(2): 170-177. (SCI)
  16. Wu TS, Tan CT, Chang CC, Lin BR, Lai WT, Chen ST, Kuo MYP, Rau CL, Jaw FS and Chang HH (2015). B-cell lymphoma/leukemia 10 promotes oral cancer progression through STAT1/ATF4/S100P signaling pathway. Oncogene 34(10): 1207-1219. (SCI)
  17. Wang CY, Chyuan IT, Wang YL, Kuo MYP, Chang CW, Wu KJ, Hsu PN, Nagasawa T, Wara-aswapati N and Chen YW (2015). beta 2-Glycoprotein I-Dependent Anti-Cardiolipin Antibodies Associated With Periodontitis in Patients With Systemic Lupus Erythematosus. Journal of Periodontology 86(8): 995-1004. (SCI)
  18. Liao MY, Lai JK, Kuo MYP, Lu RM, Lin CW, Cheng PC, Liang KH and Wu HC (2015). An anti-EpCAM antibody EpAb2-6 for the treatment of colon cancer. Oncotarget 6(28): 24947-24968. (SCI)
  19. Liao MY, Kuo MYP, Lu TY, Wang YP and Wu HC (2015). Generation of an anti-EpCAM antibody and epigenetic regulation of EpCAM in colorectal cancer. International Journal of Oncology 46(4): 1788-1800. (SCI)
  20. Ko HH, Lee JJ, Chen HM, Kok SH, Kuo MYP, Cheng SJ and Chiang CP (2015). Upregulation of vascular endothelial growth factor mRNA level is significantly related to progression and prognosis of oral squamous cell carcinomas. Journal of the Formosan Medical Association 114(7): 605-611. (SCI)
  21. Hsieh YP, Chen HM, Chang JZC, Chiang CP, Deng YT and Kuo MYP (2015). Arecoline stimulated early growth response-1 production in human buccal fibroblasts: Suppression by epigallocatechin-3-gallate. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 37(4): 493-497. (SCI)
  22. 吳金俊, 呂炫堃 and 郭彥彬 (2014). 牙周病學的醫療糾紛－臺美之經驗與比較. 臺灣牙周病醫學會雜誌 19: 195-204.
  23. Hou HH, Cheng SL, Chung KP, Kuo MYP, Yeh CC, Chang BE, Lu HH, Wang HC and Yu CJ (2014). Elastase induces lung epithelial cell autophagy through placental growth factor A new insight of emphysema pathogenesis. Autophagy 10(9): 1509-1521. (SCI)
  24. Chang PC, Chong LY, Dovban ASM, Lim LP, Lim JC, Kuo MYP and Wang CH (2014). Sequential Platelet-Derived Growth Factor-Simvastatin Release Promotes Dentoalveolar Regeneration. Tissue Engineering Part A 20: 356-364. (SCI)
  25. Yang WH, Kuo MYP, Liu CM, Deng YT, Chang HH and Chang JZC (2013). Curcumin Inhibits TGF1-induced CCN2 via Src, JNK, and Smad3 in Gingiva. Journal of Dental Research 92(7): 629-634.
  26. Yang WH, Deng YT, Kuo MYP, Liu CM, Chang HH and Chang JZC (2013). Epigallocatechin-3-gallate Blocks Triethylene Glycol Dimethacrylate-induced Cyclooxygenase-2 Expression by Suppressing Extracellular Signal-regulated Kinase in Human Dental Pulp and Embryonic Palatal Mesenchymal Cells. Journal of Endodontics 39(11): 1407-1412. (SCI)
  27. Cheng S-J, Liu Y-C, Cheng S-L, Lee J-J, Chen H-M, Chang H-H, Kok S-H, Kuo MY-P and Chiang C-P (2013). Expression of G alpha 12 predicts progression and prognosis of oral squamous cell carcinomas in Taiwan. Journal of Oral Pathology & Medicine 42(7): 565-569. (SCI)
  28. Chang PC, Chien LY, Yeo JF, Wang YP, Chung MC, Chong LY, Kuo MYP, Chen CH, Chiang HC, Ng BN, Lee QQ, Phay YK, Ng JR and Erk KY (2013). Progression of Periodontal Destruction and the Roles of Advanced Glycation End Products in Experimental Diabetes. Journal of Periodontology 84(3): 379-388. (SCI)
  29. Chang JZC, Yang WH, Deng YT, Chen HM and Kuo MYP (2013). EGCG blocks TGF beta 1-induced CCN2 by suppressing JNK and p38 in buccal fibroblasts. Clinical Oral Investigations 17(2): 455-461. (SCI)
  30. Chang CC, Yang YJ, Li YJ, Chen ST, Lin BR, Wu TS, Lin SK, Kuo MYP and Tan CT (2013). MicroRNA-17/20a functions to inhibit cell migration and can be used a prognostic marker in oral squamous cell carcinoma. Oral Oncology 49(9): 923-931. (SCI)
  31. Chang CC, Hsu WH, Wang CC, Chou CH, Kuo MYP, Lin BR, Chen ST, Tai SK, Kuo ML and Yang MH (2013). Connective Tissue Growth Factor Activates Pluripotency Genes and Mesenchymal-Epithelial Transition in Head and Neck Cancer Cells. Cancer Research 73(13): 4147-4157. (SCI)
  32. Wu PH, Lin SK, Lee BS, Kok SH, Wang JH, Hou KL, Yang H, Lai EHH, Wang JS, Hong CY (2012). Epigallocatechin-3-gallate diminishes cytokine-stimulated Cyr61 expression in human osteoblastic cells: a therapeutic potential for arthritis. Rheumatology 51(11):1953-65. (SCI)
  33. Ho MH, Chiang CP, Liu YF, Kuo MYP, Lin SK, Lai JY, Lee BS (2011). Highly Efficient Release of Lovastatin from Poly(Lactic-co-Glycolic Acid) Nanoparticles Enhances Bone Repair in Rats. Journal of Orthopaedic Research 29(10):1504-10. (SCI)
  34. Lee BS, Huang LC, Hong CY, Wang SG, Hsu WH, Yamauchi Y, Hsieh CJ, Lai JY, Wu KCW (2011). Synthesis of metal ion-histidine complex functionalized mesoporous silica nanocatalysts for enhanced light-free tooth bleaching. Acta Biomaterialia 7(5):2276-84. (SCI)
  35. Lee BS, Wang CY, Fang YY, Hsieh KH, Lin CP (2011). A Novel Urethane Acrylate-based Root Canal Sealer with Improved Degree of Conversion, Cytotoxicity, Bond Strengths, Solubility, and Dimensional Stability. Journal of Endodontics 37(2):246-49. (SCI)
  36. Yeh ST, Wang HT, Liao HY, Su SL, Chang CC, Kao HC, Lee BS (2011). The roughness, microhardness, and surface analysis of nanocomposites after application of topical fluoride gels. Dental Materials 27(2):187-96. (SCI)
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